Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study

Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study.

We assessed the effects of a single episode of maternal alcohol intoxication on fetal brain blood perfusion in three pregnant dams (baboons) at the 24th week of pregnancy using dynamic susceptibility contrast magnetic resonance imaging. After the oral administration of alcohol, there was a four-fold increase in the peak contrast concentrations in the fetal brain. In addition, we observed a two-...

Dynamic susceptibility contrast perfusion MRI (with pitfalls)

Since the first studies in the late 1980s and early 1990s, dynamic susceptibility contrast MRI (DSC-MRI, also known as ‘bolus tracking’) has become a very powerful technique for the assessment of perfusion, and perfusion-related parameters (see (1,2) for recent reviews). Despite the need of an exogenous MR agent (cf. arterial spin labeling techniques), DSC-MRI is currently the most common MR pe...

Dynamic susceptibility contrast-enhanced perfusion MR Imaging of Brain Tumors

Comparison of methods for quantitative analysis of dynamic susceptibility contrast enhanced brain perfusion MRI

Quantitative cerebral blood flow (CBF) can be obtained from dynamic susceptibility contrast (DSC) MRI using for instance the truncated singular value decomposition (tSVD). Block-circulant SVD and reformulated SVD (rSVD) are modified SVD approaches. The purpose of this study is to compare the different approaches. The optimal truncation thresholds (PSVD) for tSVD and block-circulant SVD are dete...

Perfusion MRI of the human brain with dynamic susceptibility contrast: gradient-echo versus spin-echo techniques.

In this study, spin-echo and gradient-echo-based perfusion magnetic resonance imaging (MRI) techniques are systematically compared with respect to their application in the human brain. Six healthy subjects were evaluated with both techniques consecutively and injected twice with a gadolinium-based contrast agent. In accordance with theoretical predictions and with previous animal experiments, t...